Details of the Target
General Information of Target
| Target ID | LDTP00228 | |||||
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| Target Name | Signal-regulatory protein beta-1 (SIRPB1) |
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| Gene Name | SIRPB1 | |||||
| Gene ID | 10326 | |||||
| Synonyms |
Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD antigen CD172b |
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| 3D Structure | ||||||
| Sequence |
MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSVAAGESATLRCAMTSLI
PVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYC VKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDIT LKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLR GTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETAST LIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDIT HEAALAPTAPLLVALLLGPKLLLVVGVSAIYICWKQKA |
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| Target Bioclass |
Transporter and channel
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| Subcellular location |
Cell membrane
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| Function |
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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OPA-S-S-alkyne Probe Info |
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K82(1.32) | LDD3494 | [1] | |
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DBIA Probe Info |
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C331(2.15) | LDD3427 | [2] | |
Competitor(s) Related to This Target
References