Details of the Target

General Information of Target

Target ID LDTP00222
Target Name Metabotropic glutamate receptor 8 (GRM8)
Gene Name GRM8
Gene ID 2918
Synonyms
GPRC1H; MGLUR8; Metabotropic glutamate receptor 8; mGluR8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
Target Type
Literature-reported
Target Bioclass
GPCR
Family
G-protein coupled receptor 3 family
Subcellular location
Cell membrane
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
TTD ID
T77548
Uniprot ID
O00222
DrugMap ID
TT0IFKL
Ensemble ID
ENST00000339582.7
HGNC ID
HGNC:4600
ChEMBL ID
CHEMBL3228

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.D466N .
CCK81 Deletion: p.H720TfsTer12 .
COLO792 SNV: p.G400E .
COLO800 SNV: p.L758F .
DU145 SNV: p.P254Q .
DU4475 Insertion: p.D109EfsTer28 .
EGI1 SNV: p.A736S .
HCT15 SNV: p.G489S; p.E508K .
HT115 SNV: p.M639I; p.K853N .
IGROV1 Deletion: p.K296NfsTer2 .
IPC298 SNV: p.G873E .
JHH7 SNV: p.G618Ter .
KARPAS422 SNV: p.F637C .
KMRC20 Deletion: p.Y755Ter .
KYSE410 SNV: p.K481E .
LNCaP clone FGC SNV: p.A467T .
LS180 SNV: p.F714V .
MCC13 SNV: p.G531E .
MDAMB453 SNV: p.C742Y .
NCIH1944 SNV: p.R854W .
NCIH2286 SNV: p.E524Ter; p.L830P .
NCIH2291 Substitution: p.A863E .
OVISE SNV: p.A686V .
OVK18 SNV: p.L731P .
RCC10RGB SNV: p.E779K .
SKMEL2 SNV: p.G243R .
SNGM SNV: p.G489S; p.P512S .
SW948 SNV: p.G618E .
TE11 SNV: p.A513T .
TGBC1TKB SNV: p.D466N .
UACC257 SNV: p.T685R .
WM793 SNV: p.A180V; p.G628E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		N.A.  LDD0273  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270