Details of the Target

General Information of Target

Target ID LDTP00213
Target Name Sulfotransferase 2B1 (SULT2B1)
Gene Name SULT2B1
Gene ID 6820
Synonyms
HSST2; Sulfotransferase 2B1; EC 2.8.2.2; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; Sulfotransferase family 2B member 1; Sulfotransferase family cytosolic 2B member 1; ST2B1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRD
DDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPR
LMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFL
KGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSV
VAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQ
MRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETP
HPRPS
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family
Subcellular location
Cytoplasm, cytosol
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.; [Isoform 2]: Sulfonates pregnenolone but not cholesterol.
Uniprot ID
O00204
Ensemble ID
ENST00000201586.7
HGNC ID
HGNC:11459
ChEMBL ID
CHEMBL1743297

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.K85N .
G361 Deletion: p.A5PfsTer72 .
KMRC20 SNV: p.R93L .
MFE319 SNV: p.K141E .
SW1783 SNV: p.R147H .
TF1 SNV: p.P149L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y31(18.87)  LDD3495  [1]
DBIA
 Probe Info  		C225(2.07)  LDD3319  [2]
IA-alkyne
 Probe Info  		C278(0.00); C225(0.00)  LDD0162  [3]
NAIA_5
 Probe Info  		C104(0.00); C278(0.00); C225(0.00); C81(0.00)  LDD2223  [4]
HHS-482
 Probe Info  		Y159(2.21)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C278(20.00); C225(2.15); C104(0.73)  LDD2227  [4]
 LDCM0022  KB02 AU565 C89(1.41); C225(1.79)  LDD2265  [2]
 LDCM0023  KB03 AU565 C89(2.11); C225(2.02)  LDD2682  [2]
 LDCM0024  KB05 MEWO C225(2.07)  LDD3319  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acylphosphatase-2 (ACYP2) Acylphosphatase family P14621
Sulfotransferase 1A1 (SULT1A1) Sulfotransferase 1 family P50225
Sulfotransferase 1B1 (SULT1B1) Sulfotransferase 1 family O43704
Sulfotransferase 1C3 (SULT1C3) Sulfotransferase 1 family Q6IMI6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal recognition particle subunit SRP72 (SRP72) SRP72 family O76094
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Prickle planar cell polarity protein 3 (PRICKLE3) Prickle / espinas / testin family O43900
Flagellum-associated coiled-coil domain-containing protein 1 (FLACC1) . Q96Q35

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Prasterone Small molecular drug DB01708
Pregnenolone Small molecular drug DB02789
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine 3'5'-diphosphate Small molecular drug DB01812
N-cyclohexyltaurine . DB03309

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.