Details of the Target
General Information of Target
| Target ID | LDTP00183 | |||||
|---|---|---|---|---|---|---|
| Target Name | Mitochondrial ribosome and complex I assembly factor AltMIEF1 (MIEF1) | |||||
| Gene Name | MIEF1 | |||||
| Synonyms |
AltMiD51; AltMIEF1; Mitochondrial ribosome and complex I assembly factor AltMIEF1; Alternative MIEF1 protein; AltMIEF1; MIEF1 microprotein; MIEF1-MP; alternative transcript upstream of MiD51; AltMiD51 |
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| 3D Structure | ||||||
| Sequence |
MAPWSREAVLSLYRALLRQGRQLRYTDRDFYFASIRREFRKNQKLEDAEARERQLEKGLV
FLNGKLGRII |
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| Target Bioclass |
Other
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| Family |
Complex I LYR family
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| Subcellular location |
Mitochondrion matrix
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| Function |
Assembly factor involved in the biogenesis of the mitochondrial-specific ribosomes (mitoribosomes). Specifically associates with intermediates of the mitochondrial ribosome large subunit (mt-LSU) and is required for proper ribosome assembly, possibly preventing premature association of the large and small ribosomal subunits. Thereby, indirectly regulates mitochondrial translation. It is also required for complete assembly of the mitochondrial respiratory chain complex I. May also function in DNM1L-mediated mitochondrial fission.
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| Uniprot ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K65(6.88) | LDD0277 | [1] | |
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DBIA Probe Info |
 |
C251(4.97) | LDD3310 | [2] | |
Competitor(s) Related to This Target
References