Details of the Target

General Information of Target

Target ID LDTP00172
Target Name Mapk-regulated corepressor-interacting protein 1 (MCRIP1)
Gene Name MCRIP1
Gene ID 348262
Synonyms
FAM195B; GRAN2; Mapk-regulated corepressor-interacting protein 1; Granulin-2; Protein FAM195B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSSPVSRVVYNGKRTSSPRSPPSSSEIFTPAHEENVRFIYEAWQGVERDLRGQVPGGER
GLVEEYVEKVPNPSLKTFKPIDLSDLKRRSTQDAKKS
Target Bioclass
Other
Family
MCRIP family
Subcellular location
Nucleus
Function
The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition.
Uniprot ID
C9JLW8
Ensemble ID
ENST00000455127.7
HGNC ID
HGNC:28007

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K87(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y11(19.34)  LDD3495  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.