General Information of Target

Target ID LDTP00164
Target Name Zinc finger and BTB domain-containing protein 42 (ZBTB42)
Gene Name ZBTB42
Gene ID 100128927
Synonyms
Zinc finger and BTB domain-containing protein 42
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGS
RDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQE
KDRSLDPGNPAPGAEPAQPPCPWPVWTADLCPAARKAKLPPFGVKAALPPRASGPPPCQV
PEESDQALDLSLKSGPRQERVHPPCVLQTPLCSQRQPGAQPLVKDERDSLSEQEESSSSR
SPHSPPKPPPVPAAKGLVVGLQPLPLSGEGSRELELGAGRLASEDELGPGGPLCICPLCS
KLFPSSHVLQLHLSAHFRERDSTRARLSPDGVAPTCPLCGKTFSCTYTLKRHERTHSGEK
PYTCVQCGKSFQYSHNLSRHTVVHTREKPHACRWCERRFTQSGDLYRHVRKFHCGLVKSL
LV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily
Subcellular location
Cytoplasm
Function Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
Uniprot ID
B2RXF5
Ensemble ID
ENST00000342537.8
HGNC ID
HGNC:32550

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C345(3.67)  LDD2268  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C345(3.67)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C345(6.81)  LDD2685  [1]
 LDCM0024  KB05 BRX211 C345(2.97)  LDD3102  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840