Details of the Target

General Information of Target

Target ID LDTP00144
Target Name Transcription cofactor vestigial-like protein 3 (VGLL3)
Gene Name VGLL3
Gene ID 389136
Synonyms
Transcription cofactor vestigial-like protein 3; Vgl-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSCAEVMYHPQPYGASQYLPNPMAATTCPTAYYQPAPQPGQQKKLAVFSKMQDSLEVTLP
SKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDEHFSRALGQAITLHPES
AISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPPAPCLGGVHPDFQVTGPPGTFS
AADPSPWPGHNLHQTGPAPPPAVSESWPYPLTSQVSPSYSHMHDVYMRHHHPHAHMHHRH
RHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQCDITKTEPTTVTSATSAWAGAFHG
TVDIVPSVGFDTGLQHQDKSKESPWY
Target Bioclass
Other
Family
Vestigial family
Subcellular location
Nucleus
Function May act as a specific coactivator for the mammalian TEFs.
Uniprot ID
A8MV65
Ensemble ID
ENST00000383698.3
HGNC ID
HGNC:24327

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.E205V .
HCT15 SNV: p.C277Y
Substitution: p.P186N		 .
HEC1 SNV: p.G14R .
HEC1B SNV: p.G14R .
LNCaP clone FGC SNV: p.E283Ter .
MCAS SNV: p.R108T .
MEWO SNV: p.P131L .
NCIH2291 SNV: p.P324T .
SISO SNV: p.P188T .
SNGM SNV: p.P29H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C277(1.68)  LDD3399  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 8305C C277(1.99)  LDD2248  [1]
 LDCM0023  KB03 8305C C277(2.62)  LDD2665  [1]
 LDCM0024  KB05 RBE C277(1.68)  LDD3399  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840