Details of the Target
General Information of Target
| Target ID | LDTP00142 | |||||
|---|---|---|---|---|---|---|
| Target Name | Smoothelin-like protein 1 (SMTNL1) | |||||
| Gene Name | SMTNL1 | |||||
| Gene ID | 219537 | |||||
| Synonyms |
Smoothelin-like protein 1 |
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| 3D Structure | ||||||
| Sequence |
MEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKAPAED
GMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKS EPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETG QRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAED AEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQ TSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAA SGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKF FPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELY RSLVQKGLVKTKKK |
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| Target Bioclass |
Other
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| Family |
Smoothelin family
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| Subcellular location |
Cytoplasm, myofibril
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| Function |
Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
ONAyne Probe Info |
 |
K381(1.30) | LDD0274 | [1] | |
|
DBIA Probe Info |
 |
C185(1.54) | LDD3401 | [2] | |
Competitor(s) Related to This Target
References