Details of the Target
General Information of Target
| Target ID | LDTP00136 | |||||
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| Target Name | E3 ubiquitin-protein ligase NEURL1B (NEURL1B) |
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| Gene Name | NEURL1B | |||||
| Gene ID | 54492 | |||||
| Synonyms |
NEURL3; E3 ubiquitin-protein ligase NEURL1B; EC 2.3.2.27; Neuralized-2; NEUR2; Neuralized-like protein 1B; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL1B |
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| 3D Structure | ||||||
| Sequence |
MGNTVHRTLPDPSPPARLLATRPCCGPGPERRPVLGEAPRFHAQAKGKNVRLDGHSRRAT
RRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACP DLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALI DVYGITDEVQLLESAFADTLTPARLSQARFSACLPPSSHDAANFDNNELENNQVVAKLGH LALGRAPGPPPADAAAAAIPCGPRERPRPASSPALLEADLRFHATRGPDVSLSADRKVAC APRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGVLRPNELPADPD ALLDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLGINGRPRGRLLCVDTTQALWAFFA VRGGVAGQLRLLGTLQSSPATTTPSGSLSGSQDDSDSDMTFSVNQSSSASESSLVTAPSS PLSPPVSPVFSPPEPAGIKNGECTVCFDGEVDTVIYTCGHMCLCHSCGLRLKRQARACCP ICRRPIKDVIKIYRP |
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| Target Bioclass |
Enzyme
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| Subcellular location |
Cytoplasm
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| Function | E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C300(1.51) | LDD3323 | [1] | |
Competitor(s) Related to This Target