Details of the Target

General Information of Target

Target ID LDTP00124
Target Name TANK-binding kinase 1-binding protein 1 (TBKBP1)
Gene Name TBKBP1
Gene ID 9755
Synonyms
KIAA0775; SINTBAD; TANK-binding kinase 1-binding protein 1; TBK1-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLER
ENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKN
KEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAF
SNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEA
RGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTE
LTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPC
PPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPS
CPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQ
AEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTI
RCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDD
ALIKHIDSHLENSKI
Target Bioclass
Other
Function Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
Uniprot ID
A7MCY6
Ensemble ID
ENST00000361722.7
HGNC ID
HGNC:30140
ChEMBL ID
CHEMBL4523108

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.S410R .
HCT15 SNV: p.Q107Ter; p.Q381Ter .
HEC1 SNV: p.P191H .
IM95 SNV: p.S585G .
KURAMOCHI SNV: p.R515P .
NCIH1155 SNV: p.A188T .
OVK18 SNV: p.P189T .
SUPT1 SNV: p.P401L .
TOV21G SNV: p.A491T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C360(3.58); C363(3.58)  LDD0080  [1]
IPM
 Probe Info  		C391(0.00); C163(0.00); C363(0.00); C347(0.00)  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCT 116 C360(3.58); C363(3.58)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C360(1.64); C363(1.64)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C360(2.84); C363(2.84)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) Ser/Thr protein kinase family Q14164
Serine/threonine-protein kinase TBK1 (TBK1) Ser/Thr protein kinase family Q9UHD2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RB1-inducible coiled-coil protein 1 (RB1CC1) ATG17 family Q8TDY2
Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3) . O96018

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019