Details of the Target

General Information of Target

Target ID LDTP00111
Target Name Ras association domain-containing protein 10 (RASSF10)
Gene Name RASSF10
Gene ID 644943
Synonyms
Ras association domain-containing protein 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDGCRRRRRQRRSRRLGSAGDPHG
PGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRGFERILPNKTRILRLWAAWGEE
QENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARGAPARPSLAMTQEKQRRVVRKA
FRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHESASVERMETLVHLVLSQDHTIR
QQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLVGAGIELDGSRPGEEPEEVAAE
AEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQEELLERLSAEIQEELNQRWMR
RRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLYIGLRLNTDLEAVKSDLDYSQQ
QWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPGPQACADMWVDQARGLAKSGPG
NDEDSDTGLSSMHSQDSDSLPMCESLV
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function Plays an important role in regulating embryonic neurogenesis.
Uniprot ID
A6NK89
Ensemble ID
ENST00000529419.3
HGNC ID
HGNC:33984

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C28(4.28)  LDD3444  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 SNU-478 C28(2.82)  LDD2610  [1]
 LDCM0023  KB03 SNU-478 C28(3.76)  LDD3027  [1]
 LDCM0024  KB05 SNU-478 C28(4.28)  LDD3444  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840