General Information of Target

Target ID LDTP00088
Target Name RNA-binding motif protein, Y chromosome, family 1 member B (RBMY1B)
Gene Name RBMY1B
Gene ID 378948
Synonyms
RNA-binding motif protein, Y chromosome, family 1 member B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPAD
AKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTR
GWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGS
QGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAY
RDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSR
ETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWD
EHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHA
YSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREAYGSSSYVASI
VDGGESRSEKGDSSRY
Target Bioclass
Other
Subcellular location
Nucleus
Function RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
Uniprot ID
A6NDE4
Ensemble ID
ENST00000383020.7
HGNC ID
HGNC:23914

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C85(1.26)  LDD3399  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C85(1.63); C418(2.23)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C85(1.12); C418(1.77)  LDD2660  [1]
 LDCM0024  KB05 RBE C85(1.26)  LDD3399  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840