Details of the Target

General Information of Target

Target ID LDTP00075
Target Name PH and SEC7 domain-containing protein 1 (PSD)
Gene Name PSD
Gene ID 5662
Synonyms
EFA6; EFA6A; KIAA2011; PSD1; TYL; PH and SEC7 domain-containing protein 1; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ARF6; Exchange factor for ARF6 A; Pleckstrin homology and SEC7 domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
RRKP
Target Bioclass
Other
Family
PSD family
Subcellular location
Cell membrane
Function Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling.
Uniprot ID
A5PKW4
Ensemble ID
ENST00000020673.6
HGNC ID
HGNC:9507
ChEMBL ID
CHEMBL4523105

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.S744R .
FTC133 SNV: p.E647Ter .
HCC1419 SNV: p.T652M .
HCT116 Deletion: p.P200LfsTer17 .
HCT15 SNV: p.G131V; p.P385H .
HEC1 SNV: p.G272S .
HEC1B SNV: p.R610G .
HELA SNV: p.A895P .
IGROV1 SNV: p.A415T .
IPC298 SNV: p.G482E .
J82 SNV: p.A232V .
MEWO SNV: p.P385S .
MFE319 SNV: p.P385L .
MOLT4 Deletion: p.S251AfsTer43
SNV: p.R71C		 .
RKO Deletion: p.E360KfsTer163
SNV: p.Y802H		 .
SKMEL5 SNV: p.P30S .
SSP25 SNV: p.G986R .
TE4 SNV: p.E946Q .
WM1552C SNV: p.G581C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C773(2.18)  LDD2243  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C773(2.18)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C773(2.80)  LDD2660  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840