Details of the Target
General Information of Target
| Target ID | LDTP00068 | |||||
|---|---|---|---|---|---|---|
| Target Name | Probable crossover junction endonuclease EME2 (EME2) | |||||
| Gene Name | EME2 | |||||
| Gene ID | 197342 | |||||
| Synonyms |
Probable crossover junction endonuclease EME2; EC 3.1.22.- |
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| 3D Structure | ||||||
| Sequence |
MARVGPGRAGVSCQGRGRGRGGSGQRRPPTWEISDSDAEDSAGSEAAARARDPAGERRAA
AEALRLLRPEQVLKRLAVCVDTAILEDAGADVLMEALEALGCECRIEPQRPARSLRWTRA SPDPCPRSLPPEVWAAGEQELLLLLEPEEFLQGVATLTQISGPTHWVPWISPETTARPHL AVIGLDAYLWSRQHVSRGTQQPESPKVAGAEVAVSWPEVEEALVLLQLWANLDVLLVASW QELSRHVCAVTKALAQYPLKQYRESQAFSFCTAGRWAAGEPVARDGAGLQAAWRRQIRQF SRVSPAVADAVVTAFPSPRLLQQALEACSTERERMGLLADLPVPPSEGGRPRRVGPDLSR RICLFLTTANPDLLLDLGS |
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| Target Bioclass |
Enzyme
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| Family |
EME1/MMS4 family
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| Subcellular location |
Nucleus
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| Function | Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C13(3.24) | LDD2390 | [1] | |
Competitor(s) Related to This Target