Details of the Target

General Information of Target

Target ID LDTP00067
Target Name Putative postmeiotic segregation increased 2-like protein 1 (PMS2P1)
Gene Name PMS2P1
Synonyms
PMS2L1; PMS2L13; PMS2L6; PMS2L8; PMS3; PMS8; PMSR2; Putative postmeiotic segregation increased 2-like protein 1; PMS2-related protein 2; Postmeiotic segregation increased 2-like protein 13; Postmeiotic segregation increased 2-like protein 6; Postmeiotic segregation increased 2-like protein 8; Postmeiotic segregation increased protein 3; hPMS3; Postmeiotic segregation increased protein 8; Putative postmeiotic segregation increased 2 pseudogene 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVTMCGGHRPENFLHQVLTEFGEELAGEGKSEVGGGAPRSYLQVASAECWAAAPAVHVGE
PVHAGGLHTERGADPVIGLYLVHRGGACQTPTVGNRQTPTLGIHARPRRRATTSLLTLLL
AFGKNAVRCALIGPGSLTSRTRPLTEPLGEKERREVFFPPRPERVEHNVESSRWEPRRRG
ACGSRGGNFPSPRGGSGVASLERAESSSTEPAKAIKPIDRKSVHQICSGPVVPSLSTAVK
ELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQ
VETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVK
QLFSTLPVHHKEFQRNIKKKRACFPFAFCRDCQFPEASPAMLPVQPAELTPRSTPPHPCS
LEDNVITVFSSVKNGPGSSR
Target Bioclass
Other
Family
DNA mismatch repair MutL/HexB family
Uniprot ID
A4D2B8
HGNC ID
HGNC:9123

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0025  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0023  KB03 MDA-MB-231 C129(1.66)  LDD1701  [2]

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761