Details of the Target

General Information of Target

Target ID LDTP00066
Target Name Metallo-beta-lactamase domain-containing protein 1 (MBLAC1)
Gene Name MBLAC1
Gene ID 255374
Synonyms
Metallo-beta-lactamase domain-containing protein 1; EC 3.1.27.-; Endoribonuclease MBLAC1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRTEPLCGASPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQTRGPASSHRE
SPRGSGGAEAALEEAARGPILVDTGGPWAREALLGALAGQGVAPGDVTLVVGTHGHSDHI
GNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGPGLEVWATPGHGGQRDVSVVVA
GTALGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRKRVLVVADVVVPGHGPPFRVLRE
ASQPETEGGGNSQQEPVVGDEEPALH
Target Bioclass
Enzyme
Family
Metallo-beta-lactamase superfamily, Glyoxalase II family
Subcellular location
Cytoplasm, cytosol
Function
Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.
Uniprot ID
A4D2B0
Ensemble ID
ENST00000398075.4
HGNC ID
HGNC:22180

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C7(0.72)  LDD3445  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0372  CL103 HEK-293T C7(1.12)  LDD1576  [3]
 LDCM0376  CL107 HEK-293T C7(1.17)  LDD1580  [3]
 LDCM0381  CL111 HEK-293T C7(0.98)  LDD1585  [3]
 LDCM0385  CL115 HEK-293T C7(1.26)  LDD1589  [3]
 LDCM0389  CL119 HEK-293T C7(1.25)  LDD1593  [3]
 LDCM0394  CL123 HEK-293T C7(1.10)  LDD1598  [3]
 LDCM0398  CL127 HEK-293T C7(1.12)  LDD1602  [3]
 LDCM0402  CL15 HEK-293T C7(1.22)  LDD1606  [3]
 LDCM0415  CL27 HEK-293T C7(1.49)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C7(0.82)  LDD1622  [3]
 LDCM0428  CL39 HEK-293T C7(1.02)  LDD1632  [3]
 LDCM0455  CL63 HEK-293T C7(0.73)  LDD1658  [3]
 LDCM0481  CL87 HEK-293T C7(0.90)  LDD1684  [3]
 LDCM0494  CL99 HEK-293T C7(0.87)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C7(1.08)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C7(1.18)  LDD1671  [3]
 LDCM0022  KB02 42-MG-BA C7(1.36)  LDD2244  [1]
 LDCM0023  KB03 SW1783 C7(1.22)  LDD3038  [1]
 LDCM0024  KB05 SNU-5 C7(0.72)  LDD3445  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402