Details of the Target

General Information of Target

Target ID LDTP00043
Target Name FERM domain-containing protein 3 (FRMD3)
Gene Name FRMD3
Gene ID 257019
Synonyms
EPB41L4O; FERM domain-containing protein 3; Band 4.1-like protein 4O; Ovary type protein 4.1; 4.1O
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDH
ICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIK
EELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFP
KQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFT
AAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKC
GVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANI
TQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKA
AREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDT
DSFEDLEADENAFLIAEEEELKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLL
FVFPLLLLLLESGIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS
Target Bioclass
Other
Subcellular location
Membrane
Function Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.
Uniprot ID
A2A2Y4
Ensemble ID
ENST00000304195.8
HGNC ID
HGNC:24125

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Q277R .
EGI1 SNV: p.D59H .
IGR37 SNV: p.G249E .
IGR39 SNV: p.G249E .
JURKAT SNV: p.I61V .
MCC26 SNV: p.P385S .
MFE296 SNV: p.A584D .
WM793 SNV: p.P385S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C33(2.12); C62(1.41)  LDD3383  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C33(1.79); C62(1.30)  LDD2254  [1]
 LDCM0023  KB03 A2780 C33(2.14); C62(1.37)  LDD2671  [1]
 LDCM0024  KB05 OVCAR-5 C33(2.12); C62(1.41)  LDD3383  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840