Details of the Target

General Information of Target

Target ID LDTP00031
Target Name Probable oxidoreductase PXDNL (PXDNL)
Gene Name PXDNL
Gene ID 137902
Synonyms
VPO2; Probable oxidoreductase PXDNL; EC 1.-.-.-; Cardiac peroxidase; Inactive peroxidasin-like protein; Polysomal ribonuclease 1; PRM1; Vascular peroxidase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFN
RIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKG
LISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSN
ALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEP
QDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ
GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL
ITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ
FTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQ
HDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQP
IITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI
QGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMAR
AGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSN
RCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPP
RLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP
PCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVY
GSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHR
ANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPK
VLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLP
FHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAAT
IIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPAL
MVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDN
GDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRS
AQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALR
EQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPE
LVKGTCCPVCRDRGMPSDSPEKR
Target Bioclass
Enzyme
Family
Peroxidase family, XPO subfamily
Subcellular location
Secreted; Cytoplasm
Function
Probable oxidoreductase (Probable). Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction.; [Isoform PMR1]: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.
Uniprot ID
A1KZ92
Ensemble ID
ENST00000356297.5
HGNC ID
HGNC:26359

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.G1394W .
A2058 SNV: p.G555S .
A375 SNV: p.P1432L .
AN3CA SNV: p.C718R .
CAL27 SNV: p.H638D .
CAL51 SNV: p.R690W .
COLO792 SNV: p.R917Q .
CORL23 SNV: p.N962K .
DEL SNV: p.S903Ter .
DU145 SNV: p.Q416H; p.R1319L; p.H1416Q .
G361 SNV: p.G248E .
GB2 SNV: p.V695L .
HCT15 SNV: p.H558L; p.G939C .
HEC1 SNV: p.I1141T .
HT115 SNV: p.R1319H; p.S1457R .
HUH1 SNV: p.G1032D .
IGR1 SNV: p.G259E .
IPC298 SNV: p.H558Y .
JURKAT SNV: p.A319V .
KASUMI2 SNV: p.E258D .
KMCH1 SNV: p.A1369V .
KYSE150 SNV: p.V1271I .
LNCaP clone FGC SNV: p.S273L .
LS180 SNV: p.Y128H; p.H1011N .
MCC13 SNV: p.P1288S .
MCC26 Substitution: p.E663K .
MDST8 Substitution: p.R781E .
MELHO SNV: p.P1019A .
MELJUSO SNV: p.P1019A .
MEWO SNV: p.G901R .
MFE319 SNV: p.T543S; p.R864H .
NCIH1793 SNV: p.E228Ter; p.P780H; p.E1076K .
NCIH196 SNV: p.G571V; p.T1209S .
NCIH2172 SNV: p.G1306V; p.R1463L .
NCIH23 SNV: p.D642Y; p.Y1116Ter .
NCIN87 SNV: p.R789C .
PF382 SNV: p.A744T .
RKO SNV: p.F665L; p.L1441S .
SKMEL2 SNV: p.N736D .
SUPT1 SNV: p.Q754K .
SW1271 SNV: p.C231F .
SW620 SNV: p.G587D .
SW756 SNV: p.Q1250H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C594(2.33)  LDD3318  [1]
IA-alkyne
 Probe Info  		C718(19.64)  LDD0315  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 IGR37 C594(2.08)  LDD2480  [1]
 LDCM0023  KB03 Jurkat C718(19.64)  LDD0315  [2]
 LDCM0024  KB05 MELHO C594(2.33)  LDD3318  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.