Details of the Target

General Information of Target

Target ID LDTP00008
Target Name Solute carrier family 12 member 8 (SLC12A8)
Gene Name SLC12A8
Gene ID 84561
Synonyms
CCC9; Solute carrier family 12 member 8; Cation-chloride cotransporter 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL
RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG
TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII
RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF
FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFL
IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP
VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL
REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG
EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS
KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL
GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC
RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
Target Bioclass
Transporter and channel
Family
SLC12A transporter family
Subcellular location
Membrane
Function Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.
Uniprot ID
A0AV02
Ensemble ID
ENST00000393469.8
HGNC ID
HGNC:15595

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.L656V .
HEC1 SNV: p.A348V .
HEC1B SNV: p.A348V .
IGR37 SNV: p.M621I .
IGR39 SNV: p.M621I .
LOXIMVI SNV: p.S5F .
MELJUSO SNV: p.S99R .
NCIH1793 SNV: p.V603F .
NCIH23 SNV: p.W535C .
RKO SNV: p.A624V .
SNU1 Deletion: p.G255AfsTer46 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C90(8.01)  LDD3319  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C90(1.91)  LDD2263  [1]
 LDCM0023  KB03 AGS C90(5.64)  LDD2680  [1]
 LDCM0024  KB05 MEWO C90(8.01)  LDD3319  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840