Details of the Target

General Information of Target

Target ID LDTP00006
Target Name Negative regulator of P-body association (NBDY)
Gene Name NBDY
Gene ID 550643
Synonyms
LINC01420; Negative regulator of P-body association; P-body dissociating protein; Protein NoBody
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDQPCASGRSTLPPGNAREAKPPKKRCLLAPRWDYPEGTPNGGSTTLPSAPPPASAGLK
SHPPPPEK
Target Bioclass
Other
Subcellular location
Cytoplasm, P-body
Function Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.
Uniprot ID
A0A0U1RRE5
Ensemble ID
ENST00000374922.9
HGNC ID
HGNC:50713

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D3(10.00)  LDD2209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0174  [2]
TFBX
 Probe Info  		C6(0.00); C28(0.00)  LDD0027  [3]
ENE
 Probe Info  		N.A.  LDD0006  [4]
IPM
 Probe Info  		N.A.  LDD0005  [4]
VSF
 Probe Info  		N.A.  LDD0007  [4]
Phosphinate-6
 Probe Info  		C28(0.00); C6(0.00)  LDD0018  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA-decapping enzyme 1A (DCP1A) DCP1 family Q9NPI6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enhancer of mRNA-decapping protein 4 (EDC4) WD repeat EDC4 family Q6P2E9

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004