Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	IA-alkyne			Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Experiment Method	ISO-TOP ABPP
Competitor Name	EN219			Competitor Info
Competitor Concentration	1 uM
*In Vivo* Experiment Model**	Model Type		Cell lysate
	Derived Tissue		Breast
	Disease Model	Breast cancer [ICD-11:2C82]
	Model Name	Human breast cancer cell lysate (231MFP)

Interaction Altas of This Experiment [1]

Enzyme

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Target ID	Target Name				Binding Sites	Binding Ratio
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	16.1
LDTP14083	E3 ubiquitin-protein ligase RNF114 (RNF114)				C8	2.2

Transporter and channel

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Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11916	Tubulin beta-1 chain (TUBB1)				C201	8.4

Other

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Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05079	Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12)				C97	19.3

References

1	Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.