General Information of Experiment

Probe Name DBIA  Probe Info 
Probe concentration 50 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name BDHI 14  Competitor Info 
Competitor Concentration 50 mM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 3.0
 LDTP09404  Up-regulator of cell proliferation (URGCP) C905 2.1
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00239  DNA fragmentation factor subunit alpha (DFFA) C165 2.8
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.1
 LDTP13564  YEATS domain-containing protein 2 (YEATS2) C1232 2.1

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.